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At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

BioFlux Applications

Cellular Analysis, Research, and Imaging 

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Many physiological processes take place under flow conditions: blood flowing through the vasculature; cancer cells circulating throughout the body; plaque forming on teeth under the presence of saliva flow. It is now well established that physiological flow has a profound impact on many biological studies, yet much research is still conducted in vitro without the presence of flow.

BioFlux from Fluxion Biosciences gives you the ability to introduce flow to your research and drug discovery experiments, effectively emulating in vivo conditions and revealing the true biology.

Check the application pages to see how BioFlux can accelerate your live cell assays.

“Given the critical role of shear in regulating platelet adhesion and thrombus growth, these findings may have potential pathophysiological significance.” [Jackson, et al., 2006]

Microbiology Applications

Antimicrobial Screening, Biofilm Formation, & Host-Pathogen Interactions

Hematology Applications

Thrombosis, Platelet Activity, and Atherosclerosis Models

Immunology Applications

Immune Cell Analysis, Cell Adhesion/Rolling, and Transmigration

Oncology Research Applications

Engineered T cells, CTCs, and Tumor Microenvironment

Oral Biofilms

Use saliva as media to replicate oral cavity for biofilm growth

 

Lung Biofilms

Anti-biofilm drug discovery for treatment of pulmonary diseases

 

Host-Pathogen Interactions

Form fungal and bacterial biofilms on epithelial monolayers in vitro

 

Bacterial Chemotaxis

Explore influence of genetic and morphological factors on surface motility

 

Mutant Screens

Use controlled shear flow on knockout mutant biofilms under physiologically relevant conditions

 

Medical Device Infections

PDMS and custom microfluidic plates mimic medical device infection environment

 

Antimicrobial Screens

Analyze effectiveness of novel antimicrobials on biofilm growth under shear flow

 

Adhesion Strength

Quantify biofilm adhesion and measure binding specificity in a microfluidic channel

COVID-19 Research

Study causes and treatments in COVID-19 patients

 

Migration & Invasion

Label-free, real-time measurements in situ

 

Atherosclerosis Models

Mimic arterial plaques under shear flow in vitro

 

Platelet Adhesion & Aggregation

Quantify platelet adhesion and aggregation area live

 

Thrombosis

Explore thrombus formation using whole blood

 

Sickle Cell Disease

Investigate adhesive properties of sickle erythrocytes in a simulated blood environment

 

Stem Cells

Analyze effectiveness of novel antimicrobials on biofilm growth under shear flow

 

Vascular Biology

Study vascular physiology, vascular cell-blood interactions, T-cell transmigration, wound healing, angiogenesis, mechanotransduction, and more!

Immunotherapy Development

Accelerate your engineered T cell drug discovery with functional testing of adhesion and transmigration in vitro

 

Cell Adhesion & Rolling

Utilize time-lapse microscopy under flow to quantify cell rolling and firm adhesion

 

Transmigration & Migration

Temperature-controlled transmigration experiments under shear flow

 

Rheumatology

Investigation of rheumatic disease under shear flow

 

Wound Healing

Generate more reproducible results than traditional scratch wound assays

 

Stem Cells

Investigate stem cell function under flow: homing, adhesion, transmigration, and differentiation

CAR-T/TCR Engineered T-Cell

Use saliva as media to replicate oral cavity for biofilm growth

 

Tumor Microenvironment

Control and manipulate the tumor microenvironment and test potential treatments

 

Metastasis

Examine metastasized cancer cells on endothelial monolayers and protein coatings

 

Cancer Cell Homing

Create 2 connected micro-environments to study cancer cell homing

 

Epithelial-Mesenchymal Transition

Analyze steps of cancer progression and EMT with cancer cells under shear flow

 

Cancer Cell Migration & Invasion

Create two adjacent micro-environments to analyze cell migration and invasion

 

Circulating Tumor Cells

Analyze CTC adhesion and clustering under shear flow

 

Leukemia

Examine leukocyte adhesion under shear flow conditions

 

Cancer Stem Cells

Analyze stem cell homing, adhesion, transmigration, and differentiation under flow

Customer Spotlight

Modeling of Catheter-Associated Infection

BioFlux was used in a recent study modeling catheter-associated infection by using BioFlux microfluidics to mimick the in vivo conditions of urinary catheters. In their lab, the BioFlux 200 system has been used to evaluate the efficacy of poloxamers in reducing E. coli adhesion under controllable shear forces by exploiting BioFlux silicone microfluidic flow channels, thus mimicking the in vivo conditions of urinary catheters in terms of both flow conditions and catheter material.

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