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Cell Microsystems Acquires Fluxion Biosciences to Broaden Cell Analysis Product and Services Portfolio. Read the Press Release

At Fluxion, we’re passionate about delivering cell-based solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

Thrombosis

and cardiovascular disease

It is well known that shear stress from fluid flow can have a profound impact on cellular behavior. Particularly in vascular biology, the effect of blood flow cannot be overlooked when assessing pharmacological response or the underlying mechanisms of the vasculature. In the presence of cardiovascular disease, where blood vessels can narrow almost to occlusion, the shear stress seen by the vessel wall amplifies considerably. This shear stress level significantly alters platelet and endothelial cell morphology and receptor expression.

BioFlux provides a well-controlled platform for studying thrombosis in these different shear conditions.

thrombosis+1

Whole blood with hematoporphyrin flowed through BioFlux microfluidic channels lined with endothelial cells. A microscope light was used to photochemically injure the the endothelium (A). Platelet adhesion and PF4 activation was studied in the channels. (B). Top-down (C) and sagittal (D) confocal images were taken of the endothelial damage (Poncz et al., 2017).

thrombosis+2

(A) Thrombus formation on collagen at different shear rates and time points. (B) Number of adhered platelets over time (Xi et al., 2016).

Key BioFlux Advantages For Thrombosis Studies

  • Explore of the differences in thrombus formation from donors with different or mutant genotypes

  • Discover and pre-clinically assess compounds for both anti-platelet and anti-thrombotic compounds

  • Characterize thrombosis pathways using knockout animals

  • Analyze the multiple biochemical interactions that become important for supporting platelet-surface interactions leading to thrombus formation

PUBLICATIONS & POSTERS
Dimethyl fumarate possesses antiplatelet and antithrombotic properties

 

AbstractDimethyl...
Non-canonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity

 

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The interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia

 

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Upregulation of cAMP prevents antibody-mediated thrombus formation in COVID-19

 

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Signaling through FcgRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

 

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Glycoprotein Ib Clustering In Platelets Can Be Inhibited By Alpha-Linolenic Acid As Revealed By Cryo-Electron Tomography

 

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Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine

 

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Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis

 

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Endothelial antigen assembly leads to thrombotic complications in HIT

 

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The cell motility modulator Slit2 is a potent inhibitor of platelet function.

 

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Using well-plate microfluidic devices to conduct shear-based thrombosis assays

 

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Histamine reduces GPIbα-mediated adhesion of platelets to TNF-α-activated vascular endothelium.

 

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Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads

 

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Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque

 

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Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo.

 

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The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolyticuremic syndrome in humans and mice

 

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Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate.

 

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