Evaluation of Progesterone Function in the Endothelium


Dr. Iruela Arispe,
professor and vice-chair of the Molecular, Cell and Developmental Biology at UCLA.

About the Speaker

Dr. Iruela-Arispe is professor and vice-chair of the Molecular, Cell and Developmental Biology at UCLA. She is currently the Interim Director of the Molecular Biology Institute and the Director of the Cancer Stem Cell Biology Program Area at the Jonsson Comprehensive Cancer Center at the same institution. She teaches Cell Biology for undergraduate and graduate students in addition to coordinate training for the Vascular Biology Training Grant at UCLA. She received her Ph.D. in 1989 from the University of Sao Paulo, Brazil and followed post-doctoral training at the University of Washington in Seattle. From 1994-1998 she was Assistant Professor in the Department of Pathology at Harvard Medical School and subsequently joined UCLA where she has been since 1998. She has been the recipient of many awards including the first Judah Folkman award for her contributions to the field of Angiogenesis.


It is well established that hormones, including progesterone, modulate inflammatory responses. The interaction between immune cells and the vascular endothelium play a central role in mediating the local inflammatory response in all tissues, however it is still unclear whether progesterone signals within the endothelium to regulate local inflammatory processes. Using a combination of genetic animal models and in vitro experimentation under flow, we have been able to clarify the contribution of this hormone in the vasculature. 

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