In vitro and in vivo model systems to study microbial biofilm formation.

Coenye T, Nelis HJ

J Microbiol Methods. 2010 Nov;83(2):89-105. doi: 10.1016/j.mimet.2010.08.018. Epub 2010 Sep 8.


Biofilm formation is often considered the underlying reason why treatment with an antimicrobial agent fails and as an estimated 65-80% of all human infections is thought to be biofilm-related, this presents a serious challenge. Biofilm model systems are essential to gain a better understanding of the mechanisms involved in biofilm formation and resistance. In this review a comprehensive overview of various in vitro and in vivo systems is presented, and their advantages and disadvantages are discussed.