Bacteria and fungi organized into biofilms are highly refractory to known antibiotics and biocides. To develop new solutions to combat biofilms, screening technologies must be designed to grow biofilms under conditions that represent an in vivo or in situ community while maintaining the ability to add and observe the effects of compounds. BioFlux offers a comprehensive solution for running both fundamental biology assays as well as anti-microbial compound screens.

Representative applications:

  • Biofilm growth

  • Mutant screens

  • Antibacterial or antifungal screening

  • Host-pathogen interactions

  • Adhesion strength

 
Publications & Posters
All-Silicone consumables for the study of medical device biofilm colonization
All-Silicone consumables for the study of medical device biofilm colonization
Biofilm Formation Potential of Heat Resistant Escherichia coli Dairy Isolates and Complete Genome of MDR Heat Resistant Strain FAM21845
Biofilm Formation Potential of Heat Resistant Escherichia coli Dairy Isolates and Complete Genome of MDR Heat Resistant Strain FAM21845
Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress
Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress
The ATP-Dependent Protease ClpP Inhibits Biofilm Formation by Regulating Agr and Cell Wall Hydrolase Sle1 in Staphylococcus aureus
The ATP-Dependent Protease ClpP Inhibits Biofilm Formation by Regulating Agr and Cell Wall Hydrolase Sle1 in Staphylococcus aureus
Impact of Nutrient Restriction on the Structure of Listeria monocytogenes Biofilm Grown in a Microfluidic System
Exopolysaccharide-repressing small molecules with antibiofilm and antivirulence activity against Pseudomonas aeruginosa
AraC-Type Regulator Rbf Controls the Staphylococcus epidermidis Biofilm Phenotype by Negatively Regulating the icaADBC Repressor SarR
AraC-Type Regulator Rbf Controls the Staphylococcus epidermidis Biofilm Phenotype by Negatively Regulating the icaADBC Repressor SarR
Bactericidal Effect of Strong Acid Electrolyzed Water against Flow Enterococcus faecalis Biofilms.
Bactericidal Effect of Strong Acid Electrolyzed Water against Flow Enterococcus faecalis Biofilms.
Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR).
Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR).
A high-throughput microfluidic dental plaque biofilm system to visualize and quantify the effect of antimicrobials.
A high-throughput microfluidic dental plaque biofilm system to visualize and quantify the effect of antimicrobials.
The N-terminal part of Als1 protein from Candida albicans specifically binds fucose-containing glycans.
The N-terminal part of Als1 protein from Candida albicans specifically binds fucose-containing glycans.
Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.
Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.
New device for high-throughput viability screening of flow biofilms.
New device for high-throughput viability screening of flow biofilms.
Karp-Cell Rolling JOVE video
Karp-Cell Rolling JOVE video
Shear-enhanced oral microbial adhesion.
Shear-enhanced oral microbial adhesion.
The impact of the conjugative IncP-1 plasmid pKJK5 on multi species biofilm formation is dependent on the plasmid host.
The impact of the conjugative IncP-1 plasmid pKJK5 on multi species biofilm formation is dependent on the plasmid host.
An improved medium for growing Staphylococcus aureus biofilm.
An improved medium for growing Staphylococcus aureus biofilm.
In vitro and in vivo model systems to study microbial biofilm formation.
In vitro and in vivo model systems to study microbial biofilm formation.
Effects of sub-minimum inhibitory concentrations of antimicrobial agents on Streptococcus mutans biofilm formation.
Effects of sub-minimum inhibitory concentrations of antimicrobial agents on Streptococcus mutans biofilm formation.
Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1.
Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1.
Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections.
Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections.
The impact of recombinant fusion-hydrophobin coated surfaces on E. coli and natural mixed culture biofilmformation.
The impact of recombinant fusion-hydrophobin coated surfaces on E. coli and natural mixed culture biofilmformation.
CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis.
CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis.
Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.
Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.
Inhibition of biofilm formation by esomeprazole in Pseudomonas aeruginosa and Staphylococcus aureus.
Inhibition of biofilm formation by esomeprazole in Pseudomonas aeruginosa and Staphylococcus aureus.
Antimicrobial and antibiofilm activity of pleurocidin against cariogenic microorganisms.
Antimicrobial and antibiofilm activity of pleurocidin against cariogenic microorganisms.
Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in Escherichia coli O157:H7
Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in Escherichia coli O157:H7

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